Quick answer
BPC-157 is a synthetic 15-amino-acid research peptide (Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val) with the formula C62H98N16O22, a molar mass of 1419.5 g/mol and CAS number 137525-51-0. It comes as a white to off-white lyophilized powder. A BPC-157 COA should show the lot number, HPLC purity with its chromatogram and a mass-spec identity check, and a CoreVionRX research vial holds 10mg.
BPC-157 10mg · lot-specific COA included · HPLC purity and mass-spec identity tested by an independent lab
Table of Contents
- What Is the BPC-157 Research Peptide?
- BPC-157 Key Facts
- BPC-157 Molar Mass, Formula and CAS Number
- BPC-157 Amino Acid Sequence
- BPC-157 COA: How to Read the Certificate of Analysis
- BPC-157 HPLC and Mass Spec Testing
- BPC-157 Raw Powder: Appearance and Form
- How to Reconstitute BPC-157 10mg for Lab Work
- BPC-157 Storage and Shelf Life
- BPC-157 vs TB-500 and the Blends
- What Published BPC-157 Studies Examined
- Regulatory Status
- Where to Buy BPC-157 10mg
- Frequently Asked Questions
What Is the BPC-157 Research Peptide?
The BPC-157 research peptide is a chain of 15 amino acids. Its name stands for Body Protection Compound 157, and it is also called pentadecapeptide BPC 157 or, in older development papers, PL 14736 and PLD-116.
It is a partial sequence of a larger protein, BPC, that Croatian researchers isolated from gastric juice and described in 1993 (Sikirić et al., 1993). The material sold for research today is made synthetically, typically by solid-phase peptide synthesis, not extracted from gastric juice.
CoreVionRX supplies BPC-157 as a 10mg lyophilized research peptide vial for laboratory use only.
BPC-157 Key Facts
- Sequence: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val (GEPPPGKPADDAGLV), 15 amino acids
- Molecular formula: C62H98N16O22
- Molar mass: 1419.5 g/mol (PubChem CID 9941957)
- CAS number: 137525-51-0
- Vial contents: 10mg net, white to off-white lyophilized (freeze-dried) powder
- Purity specification: ≥99% by HPLC
- Testing: each lot is checked by an independent lab for HPLC purity and mass-spec identity; the lot COA ships with the order
- Storage: sealed powder at -20°C away from light; after dissolving, 2–8°C
- Status: research use only; not an FDA-approved drug
BPC-157 Molar Mass, Formula and CAS Number
BPC-157 has a molar mass (molecular weight) of 1419.5 g/mol and the molecular formula C62H98N16O22. Its CAS number is 137525-51-0. These values come from PubChem and match the CoreVionRX product page.
| Property | BPC-157 value |
|---|---|
| Molecular formula | C62H98N16O22 |
| Molar mass (average) | 1419.5 g/mol |
| Monoisotopic mass | 1418.70 Da |
| CAS number | 137525-51-0 |
| PubChem CID | 9941957 |
| Length | 15 amino acids (pentadecapeptide) |
The molar mass is the average weight used for weighing and concentration math. The monoisotopic mass is the exact mass that a mass spectrometer looks for. Both values are for the free base; a salt form, such as an acetate, weighs more because the counter-ion adds mass.
BPC-157 Amino Acid Sequence
The BPC-157 sequence is Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val, written GEPPPGKPADDAGLV in one-letter code. It contains four prolines, three glycines, two alanines and two aspartic acids, plus one each of glutamic acid, lysine, leucine and valine.
Its developers call it a stable gastric pentadecapeptide (Sikirić et al., 2017). An anti-doping laboratory confirmed this exact sequence when it identified BPC 157 in confiscated vials by mass spectrometry (Cox et al., 2017).
BPC-157 COA: How to Read the Certificate of Analysis
A BPC-157 certificate of analysis (COA) is the lab report for one production lot. It should let you match the vial to the test and see how purity and identity were measured, not just a single percentage.
![Example layout of a BPC-157 certificate of analysis, not a real result: lot number, testing lab and date, HPLC purity with chromatogram, mass spec identity (expected 1418.70 Da, [M+2H]2+ about 710.36), form and net peptide content, appearance, endotoxin if tested, signature](https://i0.wp.com/corevionrx.com/wp-content/uploads/2026/10/How-to-read-a-BPC-157-COA-example-layout.webp?resize=1600%2C1120&ssl=1)
The graphic above is an example layout, not a real CoreVionRX report. Check these fields on any BPC-157 COA:
| COA field | What to look for |
|---|---|
| Product and lot number | The lot number matches the label on your vial |
| Testing lab and date | The lab is named and the report is dated |
| HPLC purity | A percentage with the chromatogram and method, not a bare number |
| Mass spec identity | An observed mass that matches the expected 1418.70 Da (or its charged ions) |
| Form and net peptide content | Whether the material is the free base or a salt such as acetate |
| Appearance | White to off-white lyophilized powder |
| Endotoxin (if tested) | An LAL test value, reported in EU/mg |
| Sign-off | An authorizing signature or approval |
Every CoreVionRX BPC-157 lot is tested by an independent lab before it ships, and the lot-specific COA comes with your order. For a wider walkthrough of purity, identity and endotoxin data, see the peptide COA and endotoxin testing guide.
BPC-157 HPLC and Mass Spec Testing
HPLC measures purity and mass spectrometry confirms identity. A trustworthy BPC-157 COA reports both, because a sample can be pure but the wrong peptide, or the right peptide with impurities.
HPLC purity
Reversed-phase HPLC separates BPC-157 from synthesis by-products, such as shortened or incomplete sequences. Purity is reported as the main peak’s share of the total peak area. The chromatogram should show one dominant peak, and the report should name the column, method and detection wavelength. The CoreVionRX specification for BPC-157 is ≥99% by HPLC.
Mass spec identity
Mass spectrometry checks that the main peak has the right mass. For BPC-157 the expected monoisotopic mass is 1418.70 Da. With electrospray ionization it often appears as the doubly charged ion [M+2H]2+ at about m/z 710.36, or as [M+H]+ at about m/z 1419.71. An observed mass close to these values, within the instrument’s stated tolerance, confirms the sequence weight.
BPC-157 Raw Powder: Appearance and Form
BPC-157 raw powder is the freeze-dried peptide before it is dissolved. It should look like a white to off-white powder or compact “cake” at the bottom of the vial. Clumping, a yellow or brown tint, or visible wet patches are not normal; set that vial aside and compare it with its lot COA.
The powder can be supplied as the free base or as a salt. In its review for the July 2026 advisory committee meeting, the FDA noted that BPC-157 has no settled salt, ester or free-base form (FDA Law Blog, 2026). That is why the form stated on the COA matters for weighing and concentration math.
CoreVionRX sells BPC-157 in sealed 10mg vials only, not as bulk powder by the gram.
How to Reconstitute BPC-157 10mg for Lab Work
To reconstitute BPC-157, add bacteriostatic water slowly down the inside wall of the vial and swirl gently until the powder dissolves. The volume you add only sets the concentration; the 10mg of material in the vial stays the same.
Lab prep steps:
- Let the sealed vial reach room temperature before opening, so moisture doesn’t condense on the powder.
- Wipe the stopper with an alcohol swab.
- Add the chosen volume of bacteriostatic water slowly down the vial wall, not straight onto the powder.
- Swirl gently. Don’t shake, which can cause foaming.
- Check that the solution is clear and colorless, then label the vial with lot number, date, volume added and concentration.
How Much Bacteriostatic Water for BPC-157 10mg?
There is no single required volume. Divide 10mg by the millilitres added to get the concentration in mg/mL:
| Bacteriostatic water added | BPC-157 in vial | Resulting concentration |
|---|---|---|
| 1 mL | 10mg | 10 mg/mL |
| 2 mL | 10mg | 5 mg/mL |
| 3 mL | 10mg | 3.33 mg/mL |
| 5 mL | 10mg | 2 mg/mL |
Larger volumes give lower concentrations. If several people in a lab prepare solutions, agree on one standard volume and record it the same way every time. The complete reconstitution guide covers technique in more detail.
BPC-157 Storage and Shelf Life
Store sealed BPC-157 powder frozen at -20°C, away from light and moisture. Once dissolved, keep it refrigerated at 2–8°C and avoid repeated freezing and thawing.
| State | Temperature | Notes |
|---|---|---|
| Sealed powder, long term | -20°C (freezer) | Dark and dry; use by the expiry date on the vial label |
| Sealed powder, short term | Room temperature | Brief periods only, such as shipping |
| Dissolved solution | 2–8°C (refrigerator) | Label with lot number and preparation date |
| Dissolved, repeated freezing | Not recommended | Repeated freezing and thawing can degrade peptides |
The peptide storage guide explains why light, moisture and temperature swings matter for lyophilized peptides.
BPC-157 vs TB-500 and the Blends
BPC-157 and TB-500 are different peptides that are often studied side by side. BPC-157 is a 15-amino-acid fragment of a gastric juice protein; TB-500 is a synthetic peptide related to thymosin beta-4. CoreVionRX also supplies BPC-157 inside three blends:
| Product | BPC-157 | Other components | Total |
|---|---|---|---|
| BPC-157 10mg | 10mg | None | 10mg |
| Wolverine 20mg | 10mg | TB-500 10mg | 20mg |
| GLOW 70mg | 10mg | GHK-Cu 50mg, TB-500 10mg | 70mg |
| KLOW 80mg | 10mg | GHK-Cu 50mg, TB-500 10mg, KPV 10mg | 80mg |
For a side-by-side look at the two single peptides, see BPC-157 vs TB-500. TB-500 on its own is available as TB-500 5mg.
What Published BPC-157 Studies Examined
Almost all BPC-157 research is preclinical: cell cultures and animal models, mostly rodents. Much of the early literature comes from one research group in Zagreb, and human data are very limited.
- Origin of the peptide (review). The first overview described BPC as a gastric juice protein and BPC 157 as a 15-amino-acid fragment of it, studied in many animal models (Sikirić et al., 1993, Journal of Physiology Paris).
- Tendon fibroblasts (cell culture and tissue explants). Using rat Achilles tendon explants and cultured tendon fibroblasts, researchers measured cell outgrowth, survival under oxidative stress and migration, and linked them to FAK-paxillin signaling (Chang et al., 2011, Journal of Applied Physiology).
- Blood-vessel formation (cell culture and animal). In a chick embryo membrane assay, human endothelial cells and a rat hind-limb ischemia model, BPC-157 was associated with higher VEGFR2 expression and VEGFR2-Akt-eNOS signaling (Hsieh et al., 2017, Journal of Molecular Medicine).
- Pharmacokinetics (animal). A study in rats and beagle dogs measured distribution, metabolism and excretion: the intact peptide had an elimination half-life under 30 minutes and was quickly broken down into small fragments and amino acids (He et al., 2022, Frontiers in Pharmacology).
- Musculoskeletal soft tissue (review). A review of tendon, ligament and muscle studies noted that most were done in small rodent models and that effects in humans had not been confirmed (Gwyer et al., 2019, Cell and Tissue Research).
- Orthopaedic literature (systematic review). Of 36 included studies, 35 were preclinical and 1 was clinical; the authors found no clinical safety data and flagged risks from unregulated manufacturing and contamination (Vasireddi et al., 2025, HSS Journal).
- Human evidence (systematic review). A 2026 review found three small human studies with 30 participants in total, all of poor methodological quality, and rated the certainty of evidence as very low (Poolton et al., 2026, Acta Orthopaedica Belgica).
- Detection (analytical). An anti-doping lab identified BPC 157 in confiscated vials, validated a mass-spec method for finding it in urine and described a stable metabolite (Cox et al., 2017, Drug Testing and Analysis).
What is still unknown: how the cell and animal findings relate to any other setting, how well they replicate outside the original research groups, and what the long-term safety profile is. The two systematic reviews above both point to the lack of controlled human data.
Regulatory Status
BPC-157 is not an FDA-approved drug. In April 2026 the FDA removed it from its 503A “Category 2” list of bulk substances with safety concerns for pharmacy compounding (503Pharma, 2026). On July 23, 2026, the FDA’s Pharmacy Compounding Advisory Committee voted 8 to 6, with one abstention, to recommend adding BPC-157 to the 503A bulks list (FDA Law Blog, 2026). That vote is advisory. A final listing would need notice-and-comment rulemaking, and on October 14, 2026, HHS and the FDA sent an interim access policy for compounding certain peptides to the White House Office of Management and Budget for review (Holland & Knight, 2026). As of mid-October 2026, BPC-157 is not on any final 503A list.
The World Anti-Doping Agency lists BPC-157 as a non-approved substance (class S0), prohibited for athletes at all times.
CoreVionRX sells BPC-157 strictly as a laboratory research material. It is not for human or veterinary use and is not sold as a drug, supplement or medical product.
Where to Buy BPC-157 10mg
BPC-157 10mg is available from CoreVionRX with independent HPLC purity and mass-spec identity testing and a lot-specific COA included with every order. Orders ship from the USA. See the BPC-157 10mg product page for current price and availability.
BPC-157 10mg · lot-specific COA included · ships with independent test data
Researchers who want BPC-157 together with TB-500 can compare Wolverine 20mg, GLOW 70mg and KLOW 80mg.
Frequently Asked Questions
What is BPC-157?
BPC-157 is a synthetic 15-amino-acid research peptide, Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val, taken from the sequence of a protein first isolated from gastric juice. It has the formula C62H98N16O22 and CAS number 137525-51-0, and it is studied mainly in cell-culture and animal research.
What is the molar mass of BPC-157?
The molar mass of BPC-157 is 1419.5 g/mol (PubChem CID 9941957), for the free base with formula C62H98N16O22. Its monoisotopic mass, the value a mass spectrometer looks for, is 1418.70 Da. Salt forms such as an acetate weigh more.
What should a BPC-157 COA show?
A lot number that matches your vial, HPLC purity with the method and chromatogram, a mass-spec identity result that matches the expected mass, the form (free base or salt), the testing lab’s name and report date, and a sign-off. Endotoxin data appear only if the lab ran an LAL test.
What does BPC-157 raw powder look like?
A white to off-white lyophilized powder or compact cake at the bottom of the vial. Clumping, a yellow or brown tint or wet patches are not normal; compare that vial with its lot COA.
How much bacteriostatic water do you add to BPC-157 10mg?
It depends on the concentration you want. 1 mL gives 10 mg/mL, 2 mL gives 5 mg/mL, 3 mL gives 3.33 mg/mL and 5 mL gives 2 mg/mL. The volume changes only the concentration, not the amount of material.
How should BPC-157 be stored?
Keep the sealed powder frozen at -20°C, away from light and moisture. After dissolving, refrigerate it at 2–8°C, label it with the lot number and date, and avoid repeated freezing and thawing.
Related Research Guides
- BPC-157 vs TB-500 research comparison
- GLOW 70mg research guide
- KLOW 80mg research guide
- GHK-Cu 100mg research guide
- Peptide endotoxin and COA testing
Written by the CoreVionRX Research Team. Sources: PubChem CID 9941957, the PubMed records linked above and published summaries of the FDA’s July 2026 advisory committee meeting.
For laboratory research use only. Not for human or veterinary use.
