Quick answer
The CoreVionRX CJC-1295 + Ipamorelin 10mg blend is one lyophilized vial with 5mg CJC-1295 without DAC (modified GRF 1-29) and 5mg Ipamorelin. CJC-1295 is a GHRH analog that acts at the GHRH receptor; Ipamorelin is a five-residue peptide that acts at the ghrelin receptor (GHS-R1a). Each lot is checked for HPLC purity and mass-spec identity, and the lot COA ships with the vial. Sealed powder is stored at -20°C; after dissolving in bacteriostatic water it is kept at 2–8°C.
CJC-1295 + Ipamorelin 10mg · lot-specific COA included · HPLC purity and mass-spec identity tested by an independent lab
Table of Contents
- What Is the CJC-1295 + Ipamorelin Blend?
- CJC-1295 + Ipamorelin 10mg Key Facts
- What Is in a CJC-1295 + Ipamorelin 10mg Vial?
- CJC-1295 With DAC vs Without DAC: What Does DAC Mean?
- CJC-1295 vs Ipamorelin: How the Two Peptides Differ
- CJC-1295 Ipamorelin Blend or Separate Vials?
- CJC-1295 Ipamorelin COA: What a Lab-Tested Blend Should Show
- How to Reconstitute CJC-1295 + Ipamorelin 10mg for Lab Work
- CJC-1295 Ipamorelin Storage Temperature and Appearance
- What Published Studies Examined
- Regulatory Status
- Where to Buy CJC-1295 + Ipamorelin 10mg
- Frequently Asked Questions
What Is the CJC-1295 + Ipamorelin Blend?
The CJC-1295 + Ipamorelin blend is a pre-combined research material: two peptides that act on different parts of the growth hormone axis, freeze-dried together in one vial. The CoreVionRX vial holds 10mg in total, 5mg of each.
CJC-1295 in this blend is the version without DAC, also called modified GRF (1-29). It is a 29-amino-acid analog of growth hormone-releasing hormone (GHRH). Ipamorelin is a synthetic five-residue peptide that binds the ghrelin receptor, GHS-R1a.
Researchers use the pair to look at two separate receptor pathways in the same model, from one vial, one lot and one certificate of analysis. CoreVionRX supplies the CJC-1295 + Ipamorelin 10mg blend for laboratory research use only.
CJC-1295 + Ipamorelin 10mg Key Facts
- Components: CJC-1295 without DAC (modified GRF 1-29) and Ipamorelin
- Vial contents: 10mg total net peptide, 5mg of each, lyophilized (freeze-dried) powder
- Receptors: CJC-1295 at the GHRH receptor; Ipamorelin at the ghrelin receptor (GHS-R1a)
- Testing: each lot is checked by an independent lab for HPLC purity and mass-spec identity of both peptides
- Appearance: white to off-white powder
- Storage: sealed powder at -20°C away from light and moisture; after dissolving, 2–8°C
- Status: research use only; not approved by the FDA for any use
What Is in a CJC-1295 + Ipamorelin 10mg Vial?
One vial contains 5mg CJC-1295 (no DAC) and 5mg Ipamorelin, 10mg in total. The two peptides are very different in size: CJC-1295 has 29 amino acids, Ipamorelin has five.
| Component | Amount | Sequence | Molecular formula | Molecular weight | CAS number |
|---|---|---|---|---|---|
| CJC-1295 (no DAC, modified GRF 1-29) | 5mg | Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH2 | On the lot COA | On the lot COA | On the lot COA |
| Ipamorelin | 5mg | Aib-His-D-2-Nal-D-Phe-Lys-NH2 | C38H49N9O5 | 711.9 g/mol | 170851-70-4 |
| Total | 10mg | White to off-white lyophilized powder in one sealed glass vial | |||
Ipamorelin data come from PubChem CID 9831659. PubChem has no separate entry for CJC-1295 without DAC, so its formula, weight and CAS number are taken from the lot COA rather than a general chart.
CJC-1295 without DAC (modified GRF 1-29)
Native GRF (1-29) is the first 29 amino acids of human GHRH, the shortest fragment with full activity. Modified GRF (1-29) swaps four of them: D-Ala at position 2, Gln at 8, Ala at 15 and Leu at 27. These swaps were made to slow breakdown by enzymes such as DPP-IV, which cut the native fragment quickly.
Ipamorelin
Ipamorelin is a pentapeptide developed by Novo Nordisk in the 1990s from the GHRP family. Its sequence uses two non-standard residues, Aib (2-aminoisobutyric acid) and D-2-Nal (D-2-naphthylalanine). It is also sold on its own as Ipamorelin 5mg.
CJC-1295 With DAC vs Without DAC: What Does DAC Mean?
DAC stands for Drug Affinity Complex. It is a reactive linker (a maleimidopropionamide group on an added lysine) that lets the peptide bind albumin in blood, which is what gives “CJC-1295 with DAC” its long half-life. CJC-1295 without DAC has no linker and is a different compound.
| CJC-1295 without DAC | CJC-1295 with DAC | |
|---|---|---|
| Other names | Modified GRF (1-29), Mod GRF 1-29 | CJC-1295 DAC |
| Structure | 29 amino acids, four substitutions | The same 29 amino acids plus a lysine carrying the DAC linker |
| Albumin binding | No | Yes, through the DAC linker |
| Half-life reported in studies | Short-acting (no albumin binding) | 5.8–8.1 days in healthy adults (Teichman et al., 2006) |
| Molecular formula and weight | On the lot COA | C165H269N47O46, 3647.2 g/mol (PubChem CID 91971820) |
| In the CoreVionRX 10mg blend? | Yes | No |
This matters when reading papers. Most published human data on “CJC-1295” used the DAC version, so those findings don’t transfer automatically to the no-DAC peptide in this blend. When a search, a label or a study says only “CJC-1295”, check which one it means.
CJC-1295 vs Ipamorelin: How the Two Peptides Differ
CJC-1295 and Ipamorelin are not two versions of the same thing. They bind different receptors on the pituitary’s growth-hormone cells, which is why researchers study them together.
| CJC-1295 (no DAC) | Ipamorelin | |
|---|---|---|
| Compound class | GHRH analog | Growth hormone secretagogue (ghrelin-receptor agonist) |
| Receptor | GHRH receptor | GHS-R1a (ghrelin receptor) |
| Length | 29 amino acids | 5 residues |
| Amount in the blend | 5mg | 5mg |
| Reported selectivity | Acts through the GHRH receptor | In animal studies, GH release without a matching rise in ACTH or cortisol (Raun et al., 1998) |
A related peptide on the GHRH side is Tesamorelin 10mg, another GHRH analog.
CJC-1295 Ipamorelin Blend or Separate Vials?
It depends on the study design. A blend fixes the ratio at 1:1 by weight and means one lot and one COA for both peptides; separate vials let a lab vary each peptide on its own or test one without the other.
- Blend: one vial, one lot number, one certificate of analysis, the same 5mg + 5mg in every vial. Simpler record-keeping.
- Separate vials: needed when a study isolates one compound, uses a different ratio or needs a control arm with only one peptide.
A blend can’t be split back into its parts after it is made, so studies that need either peptide alone use single-peptide vials such as Ipamorelin 5mg.
CJC-1295 Ipamorelin COA: What a Lab-Tested Blend Should Show
A blend COA should prove both peptides are present and correct, not only that the vial holds 10mg of powder. “Lab tested” or “third-party tested” means little unless the report itself shows the points below.
Check these on any CJC-1295 + Ipamorelin certificate of analysis:
- Lot number that matches the label on your vial.
- Both components named, with the milligrams of each (5mg + 5mg for this blend) and the total.
- HPLC purity with the method and chromatogram, ideally a separate peak and purity figure for each peptide.
- Mass-spec identity for each peptide: the measured mass should match the expected mass of CJC-1295 (no DAC) and of Ipamorelin (711.9 g/mol).
- Which CJC-1295: the report should say no DAC or modified GRF (1-29). A mass near 3647 g/mol would point to the DAC version instead.
- Lab name, report date and sign-off from the testing laboratory.
Endotoxin testing is a separate test from HPLC and mass spec; the peptide endotoxin and COA testing guide explains what it measures.
How to Reconstitute CJC-1295 + Ipamorelin 10mg for Lab Work
To reconstitute the blend, add bacteriostatic water slowly down the inside wall of the vial and swirl gently until the powder dissolves. Both peptides dissolve together into one solution. The volume you add sets the concentration only; the 10mg of peptide stays the same.
Lab prep steps:
- Let the sealed vial reach room temperature before opening, so moisture doesn’t condense on the powder.
- Wipe the stopper with an alcohol swab.
- Add the chosen volume of bacteriostatic water slowly down the vial wall, not straight onto the powder.
- Swirl gently. Don’t shake, which can cause foaming.
- Check that the solution is clear and colorless, then label the vial with lot number, date, volume added and concentration.
How Much Bacteriostatic Water for CJC-1295 + Ipamorelin 10mg?
There is no single required volume. Divide 10mg by the millilitres added for the total blend concentration, and 5mg by the same volume for each peptide:
| Bacteriostatic water added | Total blend concentration | CJC-1295 (no DAC) | Ipamorelin |
|---|---|---|---|
| 1 mL | 10 mg/mL | 5 mg/mL | 5 mg/mL |
| 2 mL | 5 mg/mL | 2.5 mg/mL | 2.5 mg/mL |
| 3 mL | 3.33 mg/mL | 1.67 mg/mL | 1.67 mg/mL |
| 5 mL | 2 mg/mL | 1 mg/mL | 1 mg/mL |
Larger volumes give lower concentrations. If several people in a lab prepare solutions, agree on one standard volume and record it the same way every time. The complete reconstitution guide covers technique in more detail.
CJC-1295 Ipamorelin Storage Temperature and Appearance
Store the sealed vial frozen at -20°C, away from light and moisture. Once the powder is dissolved, keep the solution refrigerated at 2–8°C and protected from light.
- Sealed powder: -20°C, dark, dry. Keep the vial closed until it has warmed to room temperature.
- Dissolved solution: 2–8°C, protected from light. Don’t refreeze it; if a study needs small portions, split the solution into aliquots once rather than freezing and thawing the whole vial repeatedly.
- Appearance: the powder is white to off-white and may look like a compact cake or loose flakes. The dissolved solution should be clear and colorless.
- When to set a vial aside: cloudiness, visible particles, a yellow or brown tint, or powder that looks wet before it is opened. Compare that vial with its lot COA.
More general handling advice is in the peptide storage guide.
What Published Studies Examined
No published studies test this exact 5mg + 5mg blend. The studies below look at each peptide on its own, and the CJC-1295 work used the DAC version, which is a different compound from the no-DAC peptide in this vial.
- Ipamorelin’s selectivity (cell and animal study). Novo Nordisk researchers described ipamorelin in rat pituitary cells, anaesthetised rats and conscious swine. It released growth hormone with a potency similar to GHRP-6 and, unlike GHRP-6 and GHRP-2, did not raise ACTH or cortisol above the levels seen with GHRH; FSH, LH, prolactin and TSH were unaffected (Raun et al., 1998, Eur J Endocrinol).
- Ipamorelin and bone growth in rats (animal study). Over 15 days in adult female rats, researchers measured a higher longitudinal bone growth rate in the ipamorelin groups than in controls, with no change in total IGF-I or in bone-turnover markers (Johansen et al., 1999, Growth Horm IGF Res).
- Ipamorelin in hospital patients (human phase 2 trial). A randomized, double-blind, placebo-controlled trial in 114 adults after bowel surgery studied ipamorelin for postoperative ileus. It found no significant difference from placebo in the main or secondary efficacy measures (Beck et al., 2014, Int J Colorectal Dis).
- How CJC-1295 with DAC was designed (cell and animal study). Researchers at ConjuChem made albumin-binding versions of GRF (1-29) and picked CJC-1295, a four-substitution GRF (1-29) with the DAC linker, as the best candidate; in rats it was still present in plasma beyond 72 hours (Jetté et al., 2005, Endocrinology).
- CJC-1295 with DAC in healthy adults (human trials). Two randomized, placebo-controlled, double-blind trials measured growth hormone and IGF-I levels and the compound’s pharmacokinetics; they reported raised levels lasting several days and an estimated half-life of 5.8–8.1 days (Teichman et al., 2006, J Clin Endocrinol Metab).
- CJC-1295 with DAC in GHRH-knockout mice (animal study). In mice lacking the GHRH gene, researchers reported normal body weight and length in one of the study groups, along with higher pituitary GH mRNA (Alba et al., 2006, Am J Physiol Endocrinol Metab).
What is unknown: there is very little published data on modified GRF (1-29) without DAC on its own, and none on this blend. Findings from one species or one compound shouldn’t be read as applying to another.
Regulatory Status
Neither CJC-1295 nor Ipamorelin is approved by the FDA for any use. On the FDA’s list of bulk drug substances that may present significant safety risks in compounding (updated April 2026), ipamorelin acetate sits in category 2 under the 503B interim policy (added September 29, 2023), and CJC-1295 appears as a nominated substance that was withdrawn, with FDA noting serious adverse events and limited clinical data (FDA).
In sport, the World Anti-Doping Agency’s Prohibited List names both in class S2: CJC-1295 among GHRH analogues and ipamorelin among growth hormone secretagogues. CoreVionRX sells this blend strictly as a laboratory research material.
Where to Buy CJC-1295 + Ipamorelin 10mg
CoreVionRX supplies the CJC-1295 + Ipamorelin 10mg blend (5mg CJC-1295 without DAC + 5mg Ipamorelin) with a lot-specific COA. Orders ship from the USA to US addresses; see the shipping policy for times and rates. For single-peptide work, see Ipamorelin 5mg and Tesamorelin 10mg.
CJC-1295 + Ipamorelin 10mg · 5mg + 5mg · lot-specific COA included
Frequently Asked Questions
What is in the CJC-1295 + Ipamorelin 10mg blend?
One lyophilized vial with 10mg of peptide: 5mg CJC-1295 without DAC (modified GRF 1-29) and 5mg Ipamorelin. The lot certificate of analysis confirms both components.
Is the CJC-1295 in this blend with or without DAC?
Without DAC. DAC (Drug Affinity Complex) is an albumin-binding linker; CJC-1295 with DAC is a different, longer-lasting compound with a molecular weight of 3647.2 g/mol in PubChem.
What does DAC stand for in peptides?
DAC stands for Drug Affinity Complex, a reactive linker added to a peptide so it binds albumin in blood. In CJC-1295 with DAC it extends the half-life to several days in published human studies.
How much bacteriostatic water do you add to CJC-1295 + Ipamorelin 10mg?
It depends on the concentration you want. 1 mL gives 10 mg/mL of total blend, 2 mL gives 5 mg/mL, 3 mL gives 3.33 mg/mL and 5 mL gives 2 mg/mL. Each peptide is half of the total figure.
What is the storage temperature for CJC-1295 + Ipamorelin?
Keep the sealed vial frozen at -20°C, away from light and moisture. After the powder is dissolved, keep the solution refrigerated at 2–8°C and protected from light.
What should a CJC-1295 Ipamorelin COA show?
A lot number that matches your vial, the milligrams of each peptide, HPLC purity with the chromatogram, mass-spec identity for both CJC-1295 (no DAC) and Ipamorelin, and the testing lab’s name, report date and sign-off.
Related Research Guides
- KLOW 80mg research guide
- GLOW 70mg research guide
- Epitalon 10mg research guide
- Endotoxin and COA testing guide
- Peptide storage guide
Written by the CoreVionRX Research Team. Sources: PubChem CIDs 9831659 and 91971820, the FDA bulk drug substances page and the PubMed records linked above.
For laboratory research use only. Not for human or veterinary use.
