
TB-500 Peptide (Thymosin Beta-4) Lab Grade Research Peptide — ≥99% Purity
100 in stock
What is TB-500?
TB-500 is a 43-amino-acid peptide corresponding to the active region of Thymosin Beta-4. The N-terminus is acetylated. It binds actin — the protein that forms cellular cytoskeleton filaments — and researchers study it for cell migration, wound healing, angiogenesis, and tissue repair mechanisms.
Thymosin Beta-4 is a 43-amino-acid peptide originally isolated from bovine thymus tissue. TB-500 refers to the synthetic version of this same sequence. Research models include cardiac tissue repair, dermal wound closure, and cell motility assays.
- Sequence: 43 amino acids, N-terminally acetylated
- Source: Synthetic fragment of Thymosin Beta-4
- Mechanism: Actin-binding, cell migration regulation
- Verification: HPLC + electrospray mass spectrometry
- Documentation: COA with chromatogram included
Contents: One vial containing 10mg TB-500 as lyophilized powder.
For laboratory research use only. Not for human or animal consumption.
TB-500 Research Applications
Researchers across the globe study TB-500 for its potential applications in cellular biology, tissue engineering, regenerative medicine, and molecular signaling pathways. Laboratory studies have explored its role in:
- Cell culture and proliferation assays
- Molecular binding and receptor interaction studies
- Tissue regeneration and wound healing models
- Biochemical pathway analysis
- Pharmacokinetic and stability profiling
Note: TB-500 sold by CoreVionRX is intended strictly for research purposes. It is not intended for human consumption, diagnostic use, or therapeutic application.
Product Features
- 99%+ Purity: Every batch exceeds 99% purity as verified by HPLC analysis.
- Lyophilized Form: Freeze-dried powder for maximum stability and extended shelf life.
- COA Included: Full Certificate of Analysis provided with every order.
- USA Shipping: Fast domestic delivery from our US-based facility.
- Discreet Packaging: Plain, unmarked packaging protects your privacy.
- Secure Storage: Vials are sealed and shipped with temperature protection.
Why Buy TB-500 from CoreVionRX?
Detailed Description
TB-500, also known as Thymosin Beta-4 (TB-4 or Tβ4), is a 43-amino-acid peptide studied extensively for its role in cellular regeneration and wound healing. This TB-500 5mg lyophilized research peptide is synthesized to match the active region of the naturally occurring Thymosin Beta-4 found in mammalian tissues.
What Is TB-500?
TB-500 is a synthetic peptide analog of Thymosin Beta-4, a protein that regulates actin—the primary structural component of cellular cytoskeletons. Researchers investigate TB-500 for its potential to enhance cell migration, wound healing, angiogenesis (formation of new blood vessels), and tissue repair mechanisms. The peptide's mechanism centers on actin sequestration and regulation of cell motility, making it a candidate compound for studying recovery in musculoskeletal and cardiovascular research models.
TB-500 Research Applications
Preclinical literature documents TB-500 under investigation for:
- Cell migration and wound closure studies
- Soft tissue and tendon repair models
- Angiogenesis and vascular formation assays
- Cardiac tissue regeneration following injury
- Cytoskeletal dynamics and actin regulation
- Muscle fiber development and recovery
- Dermal wound healing and fibroblast activity
How TB-500 Works
TB-500 binds actin monomers and regulates their availability for polymerization into filaments. This actin-binding mechanism influences cell migration rates, focal adhesion formation, and the regulation of ILK-AKT cell survival signaling pathways. The result is enhanced cellular motility and wound closure in research models. Additionally, TB-500 is studied for systemic effects on inflammation and tissue repair cascades.
TB-500 Specifications
| Compound | TB-500 (Thymosin Beta-4) |
|---|---|
| Quantity | 5mg per vial (lyophilized) |
| Form | Lyophilized powder |
| Purity | ≥99% (HPLC verified) |
| Storage | -20°C (lyophilized); 2-8°C (reconstituted) |
| CAS Number | Available on COA |
| Molecular Weight | Available on COA |
| Appearance | White to off-white lyophilized powder |
| Packaging | Sealed sterile glass vial |
Quality Assurance
- HPLC purity verification (≥99%)
- Mass spectrometry identity confirmation
- Endotoxin and microbial contamination testing
- Certificate of Analysis (COA) included with every order
Reconstitution & Handling
TB-500 5mg is reconstituted with bacteriostatic water for laboratory research. Researchers typically add bacteriostatic water slowly down the inside wall of the vial to minimize foaming and ensure complete dissolution. Once reconstituted, store at 2-8°C and protect from light. Prepare small aliquots to avoid repeated freeze-thaw cycles, which can degrade the peptide. Always follow your institution's protocols for peptide handling and documentation.
Frequently Asked Questions
What is TB-500 and what does it do?
TB-500 is a synthetic peptide based on Thymosin Beta-4 (Tβ4), a 43-amino-acid protein involved in cell migration and actin regulation. Researchers study it for wound healing, tissue repair, and angiogenesis in laboratory models.
What is the purity of CoreVionRX TB-500?
CoreVionRX TB-500 5mg is ≥99% purity, verified by HPLC analysis and confirmed by mass spectrometry. Each batch includes a Certificate of Analysis documenting purity and sterility testing.
How should TB-500 be stored?
Store the lyophilized vial at -20°C for maximum stability. After reconstitution with bacteriostatic water, store at 2-8°C, protect from light, and use within your institutional guidelines. Avoid repeated freeze-thaw cycles.
How is TB-500 reconstituted for research?
TB-500 5mg is typically reconstituted with bacteriostatic water. Add the diluent slowly down the vial wall, allow the powder to dissolve, and prepare aliquots for storage. Follow your lab's standard protocols for peptide preparation and documentation.
TB-500 is supplied strictly for laboratory and research use only. Not for human or animal consumption.
Sources & References:Frequently Asked Questions About TB-500
Common questions from researchers buying TB-500 for laboratory studies.
What is TB-500 used for in research?
TB-500 is a synthetic peptide extensively studied for its potential applications in tissue regeneration, cellular repair, and molecular biology research. Laboratory studies investigate its mechanisms at the cellular level, including receptor binding, signal transduction, and gene expression pathways. It is widely used in in vitro assays and biochemical profiling.
How do I reconstitute TB-500 for research?
Reconstitute lyophilized TB-500 using bacteriostatic water. Slowly inject the diluent along the inner wall of the vial. Do not shake vigorously — gentle swirling is preferred. Allow the peptide to dissolve naturally over 1-2 minutes. Once reconstituted, store the solution at 2-8°C and use within 30 days for optimal stability.
What is the shelf life of lyophilized TB-500?
When stored properly at -20°C in a sealed container away from direct light and moisture, lyophilized TB-500 remains stable for 24-36 months from the date of manufacture. The expiration date is printed on each vial label. Always check the COA for batch-specific stability data.
Is TB-500 HPLC verified?
Yes. Every batch of CoreVionRX TB-500 undergoes rigorous High-Performance Liquid Chromatography (HPLC) testing to verify purity of 99% or greater. A Certificate of Analysis (COA) is included with each order, documenting the HPLC chromatogram, mass spectrometry data, and batch-specific test results.
Where can I buy lab grade TB-500 in the USA?
CoreVionRX supplies high-purity, lab grade TB-500 directly from our USA-based facility. We offer fast domestic shipping (typically 2-5 business days), discreet packaging, and a 30-day satisfaction guarantee for qualified research applications. All orders ship from within the United States.
What purity level does CoreVionRX TB-500 guarantee?
CoreVionRX guarantees a minimum purity of 99%+ on all TB-500 batches. This is verified via HPLC and mass spectrometry, with complete results documented on the included Certificate of Analysis. If a batch does not meet this standard, it is rejected and never shipped to customers.
How should TB-500 be stored?
Store lyophilized TB-500 in a freezer at -20°C. Once reconstituted, refrigerate at 2-8°C. Always protect from direct light and moisture. Use within 30 days of reconstitution for optimal stability. Do not freeze reconstituted solution.
What form does TB-500 come in?
TB-500 is supplied as a lyophilized (freeze-dried) powder in a sterile glass vial sealed with a rubber stopper. This form maximizes stability during shipping and enables long-term storage. The powder is reconstituted with bacteriostatic water immediately before laboratory use.
Does CoreVionRX ship TB-500 discreetly?
Yes. All CoreVionRX orders are shipped in plain, unmarked packaging with no indication of contents on the exterior. We prioritize your privacy and the security of your research materials. The return address is generic, and no branding appears on the outside of the package.
Can I return TB-500 if I am not satisfied?
CoreVionRX offers a 30-day satisfaction guarantee on unopened, properly stored products. Please contact our support team within 30 days of delivery to initiate a return authorization. Items must be in original packaging with the seal intact. Custom or bulk orders may have different return terms.
What is the difference between research grade and lab grade TB-500?
CoreVionRX supplies lab grade TB-500, which exceeds standard "research grade" definitions. Our peptides undergo more rigorous analytical testing (HPLC + MS), are manufactured under stricter conditions, and come with full documentation. Lab grade is the preferred standard for peer-reviewed research and publication-quality work.
How quickly does CoreVionRX ship TB-500 orders?
Orders placed before 2:00 PM EST ship the same business day. Standard shipping typically takes 2-5 business days within the continental USA. Express shipping options are available at checkout. You will receive tracking information via email once your TB-500 order ships.
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All orders over $400 ship free within the continental USA. Standard delivery in 2-5 business days.
Discreet Packaging
Plain, unmarked packaging with no indication of contents. Your privacy is our priority.
30-Day Guarantee
Unopened, properly stored products can be returned within 30 days. Contact us for an RA number.
Same-Day Shipping
Orders placed before 2:00 PM EST ship the same business day. Track your package from our facility.
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