MOTS-c — 16-amino-acid mitochondrial-derived peptide encoded in the mitochondrial genome. Studied for AMPK activation, metabolic regulation, and insulin sensitivity in preclinical models. 40mg lyophilized, HPLC verified.
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a 16-amino-acid peptide encoded within the mitochondrial genome — not the nuclear genome — making it part of a newly characterized class of mitochondrial-derived peptides (MDPs). It was first characterized in 2015 and has since attracted significant research interest for its role in metabolic regulation.
In preclinical studies, MOTS-c is investigated for its ability to activate AMPK (AMP-activated protein kinase), regulate glucose metabolism, influence insulin sensitivity, and modulate the folate cycle. Researchers also study its potential role in exercise physiology and age-related metabolic decline.
For a full breakdown of the research literature, read our MOTS-c research guide →
CoreVionRX doesn’t manufacture peptides. What we do — rigorously — is verify every batch before it reaches our catalog.
Everything you need to evaluate this compound for your research protocol.
| Specification | Value |
|---|---|
| Compound | MOTS-c (Mitochondrial-Derived Peptide) |
| Origin | Encoded in mitochondrial 12S rRNA gene |
| Amino Acids | 16 |
| Form | Lyophilized powder |
| Vial Size | 40mg per vial |
| Purity | ≥98% by reversed-phase HPLC |
| Identity | Confirmed by electrospray ionization mass spectrometry |
| Storage (lyophilized) | −20°C, protected from light and moisture. Stable 24+ months. |
| Reconstitution | Bacteriostatic water or sterile water |
| Documentation | Lot-specific COA with HPLC chromatogram — included with every order |
All published research is preclinical — cell cultures and animal models. No human clinical trial data exists for MOTS-c. Here’s where the science currently stands.
Lee C. et al. (2015) Cell Metab 21(3):443-54
Kim SJ. et al. (2018) Proc Natl Acad Sci 115(30):7592-7
Reynolds JC. et al. (2021) Nat Metab 3(9):1271-86
Most peptide vendors claim purity. We document it. Every compound ships with independent lab verification — not because regulations require it, but because you deserve to know exactly what you’re working with.
In stock. COA included. HPLC + mass spec verified. Ships with full documentation.
For laboratory research use only. Not for human or animal consumption.
CoreVionRX supplies research compounds to qualified laboratories and research institutions.
Documentation & Testing Standards
Every batch is independently tested before release. Research peptide FAQs · CoreVionRX testing standards
Related Research Compounds