COA included with every order For laboratory research use only
HPLC Verified≥98% purity confirmed per lot
COA IncludedLot-specific certificate ships with order
Mass Spec IDMolecular identity confirmed per batch
USA OperationsVerified sourcing. Documented chain.
About This Compound
What Is MOTS-c?
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a 16-amino-acid peptide encoded within the mitochondrial genome — not the nuclear genome — making it part of a newly characterized class of mitochondrial-derived peptides (MDPs). It was first characterized in 2015 and has since attracted significant research interest for its role in metabolic regulation.
In preclinical studies, MOTS-c is investigated for its ability to activate AMPK (AMP-activated protein kinase), regulate glucose metabolism, influence insulin sensitivity, and modulate the folate cycle. Researchers also study its potential role in exercise physiology and age-related metabolic decline.
CoreVionRX doesn’t manufacture peptides. What we do — rigorously — is verify every batch before it reaches our catalog.
≥98%
Purity by Reversed-Phase HPLC
HPLC separates the compound from any impurities and measures the exact purity percentage. The chromatogram is documented on your COA — not a number we made up.
MS/MS
Mass Spectrometry Identity Check
Electrospray ionization mass spectrometry verifies the molecular weight matches the compound specification. This confirms you’re getting the actual compound — not a substitute or mis-labeled batch.
Lot #
Lot-Specific Certificate of Analysis
Your COA is tied to your specific production lot — not a generic document. This is not standard practice in this market. We made it one anyway.
100%
Documented Before Listing
No compound reaches our catalog without clearing our verification process first. If documentation isn’t available for a batch, that batch doesn’t ship.
Technical Specifications
Full Product Data
Everything you need to evaluate this compound for your research protocol.
Specification
Value
Compound
MOTS-c (Mitochondrial-Derived Peptide)
Origin
Encoded in mitochondrial 12S rRNA gene
Amino Acids
16
Form
Lyophilized powder
Vial Size
40mg per vial
Purity
≥98% by reversed-phase HPLC
Identity
Confirmed by electrospray ionization mass spectrometry
Storage (lyophilized)
−20°C, protected from light and moisture. Stable 24+ months.
Reconstitution
Bacteriostatic water or sterile water
Documentation
Lot-specific COA with HPLC chromatogram — included with every order
Preclinical Research
What Researchers Study MOTS-c For
All published research is preclinical — cell cultures and animal models. No human clinical trial data exists for MOTS-c. Here’s where the science currently stands.
Mitochondrial Metabolism Research
MOTS-c is studied for its role in AMPK activation and mitochondrial biogenesis. Preclinical research investigates how this mitochondrial-encoded peptide regulates cellular energy production and metabolic homeostasis.
Lee C. et al. (2015) Cell Metab 21(3):443-54
Insulin Sensitivity Studies
Research in rodent models has investigated MOTS-c’s role in improving insulin sensitivity and glucose metabolism. Studies examine its effects on skeletal muscle glucose uptake and hepatic glucose production.
Kim SJ. et al. (2018) Proc Natl Acad Sci 115(30):7592-7
Exercise Physiology Research
MOTS-c levels are observed to increase with physical activity in animal models. Researchers study how this mitochondrial peptide mediates exercise adaptations including endurance, fatigue resistance, and metabolic efficiency.
Reynolds JC. et al. (2021) Nat Metab 3(9):1271-86
Why CoreVionRX
Documentation Is the Product.
Most peptide vendors claim purity. We document it. Every compound ships with independent lab verification — not because regulations require it, but because you deserve to know exactly what you’re working with.
Independent HPLC Testing
Every batch runs through reversed-phase HPLC before we list it. The chromatogram appears on your COA. Verify the peak profile yourself.
Lot-Specific Documentation
Your COA is tied to your production lot — not a template document used across all orders. “COA available upon request” is not how we operate.
Transparent About What We Are
We source and verify. We are not a synthesis lab. That honesty is deliberate — it’s the only way to build a brand worth buying from twice.
Lyophilized for Stability
Ships as lyophilized powder — stable at −20°C for 24+ months. Full integrity maintained until you’re ready to reconstitute.
Common Questions
Straight Answers.
What is MOTS-c and what makes it unique?
MOTS-c is a 16-amino-acid peptide encoded within the mitochondrial genome — unlike most peptides which are nuclear genome-encoded. First characterized in 2015, it belongs to a new class called mitochondrial-derived peptides (MDPs). It is studied for its role in metabolic regulation through AMPK activation.
What does MOTS-c research focus on?
Research focuses on MOTS-c’s role in mitochondrial metabolism, AMPK pathway activation, insulin sensitivity, skeletal muscle glucose uptake, and exercise physiology. All research is preclinical — no human clinical data exists.
Why does MOTS-c come in a 40mg vial?
MOTS-c is typically used at higher concentrations in research protocols than shorter peptides, and the 40mg format reduces the need for frequent reordering in lab settings. Each vial ships with a lot-specific COA confirming purity.
How do I reconstitute MOTS-c?
Reconstitute with bacteriostatic water or sterile water depending on your protocol. Gently swirl — do not shake. Use our reconstitution calculator for exact volumes based on your target concentration.
How should MOTS-c be stored?
Store lyophilized at −20°C, protected from light and moisture. Stable for 24+ months. Once reconstituted, store at 2–8°C. Aliquot before reconstituting to preserve compound integrity across multiple preparations.
For laboratory research use only. Not for human or animal consumption. CoreVionRX supplies research compounds to qualified laboratories and research institutions.
MOTS-c Research Peptide: What to Know Before You Buy
mots-c research peptide from CoreVionRX is verified at ≥99%% HPLC purity with mass spectrometry confirming the exact peptide sequence.
Every mots-c research peptide vial ships with HPLC verification and a lot-specific COA.
Every vial of mots-c research peptide ships with a lot-specific certificate of analysis so you can verify exactly what is in the vial you received.
CoreVionRX mots-c research peptide is verified by independent third-party testing — mass spectrometry confirms sequence identity and HPLC confirms purity.
Store mots-c research peptide as a lyophilized powder in cool, dark conditions; once reconstituted, keep refrigerated and use within your protocol window.
For accurate reconstitution of mots-c research peptide, use the peptide calculator to calculate the exact water volume needed.
Researchers working with mots-c research peptide should confirm ≥99%% HPLC purity and a lot-specific COA with every order.
For reconstitution, add bacteriostatic water slowly and store mots-c research peptide refrigerated after mixing. Use the peptide calculator to get concentration right.
When sourcing mots-c research peptide, the most important check is purity: every CoreVionRX vial is verified at ≥99% HPLC with a lot-specific COA.
Peer-reviewed research on mots-c research peptide is indexed at PubMed. For research use only.
All CoreVionRX research peptides ship with a lot-specific COA, ≥99%% HPLC purity, and mass-spec identity confirmation. Use our reconstitution calculator for prep. For research use only.
Sourcing verified mots-c research peptide is the first step in any reliable research protocol.
