MOTS-c 40MG Lab Grade Research Peptide — ≥99% Purity
42 in stock
What is MOTS-c?
MOTS-c is a 16-amino-acid peptide encoded by the mitochondrial 12S rRNA gene (MT-RNR1). The sequence is MRWEQENPVNHMAVAN. Unlike nuclear-encoded peptides, MOTS-c is synthesized inside mitochondria and researchers study it for metabolic regulation, insulin sensitivity, and cellular energy homeostasis.
This is a 40mg vial — a higher quantity than the standard 5mg or 10mg formats most suppliers stock. Metabolic research protocols often require more material per experiment, which is why we offer this format. HPLC and mass spec verified. COA included.
- Sequence: MRWEQENPVNHMAVAN — 16 amino acids
- Origin: Mitochondrial 12S rRNA (MT-RNR1 gene)
- Class: Mitochondrial-derived peptide (MDP)
- Dose format: 40mg (higher than standard)
- Verification: HPLC + electrospray mass spectrometry
- Documentation: COA with chromatogram included
Contents: One vial containing 40mg MOTS-c as lyophilized powder.
For laboratory research use only. Not for human or animal consumption.
MOTS-c Research Applications
Researchers across the globe study MOTS-c for its potential applications in cellular biology, tissue engineering, regenerative medicine, and molecular signaling pathways. Laboratory studies have explored its role in:
- Cell culture and proliferation assays
- Molecular binding and receptor interaction studies
- Tissue regeneration and wound healing models
- Biochemical pathway analysis
- Pharmacokinetic and stability profiling
Note: MOTS-c sold by CoreVionRX is intended strictly for research purposes. It is not intended for human consumption, diagnostic use, or therapeutic application.
Product Features
- 99%+ Purity: Every batch exceeds 99% purity as verified by HPLC analysis.
- Lyophilized Form: Freeze-dried powder for maximum stability and extended shelf life.
- COA Included: Full Certificate of Analysis provided with every order.
- USA Shipping: Fast domestic delivery from our US-based facility.
- Discreet Packaging: Plain, unmarked packaging protects your privacy.
- Secure Storage: Vials are sealed and shipped with temperature protection.
Why Buy MOTS-c from CoreVionRX?
Detailed Description
MOTS-c — MOTS-c is a mitochondrial-derived peptide that regulates metabolic homeostasis by activating the MOTS-c-TAKR25 pathway. This MOTS-c 40mg lyophilized research peptide is investigated for its unique role in mitochondrial function, metabolic regulation, cellular stress response, and age-related metabolic decline.
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a 16-amino-acid peptide encoded within the mitochondrial 12S rRNA gene. Unlike typical peptides, MOTS-c 40mg acts as a circulating mitochondrial hormone that regulates metabolic function systemically. Researchers study MOTS-c 40mg for its potential to enhance insulin sensitivity, reduce metabolic dysfunction, activate autophagy, and extend healthspan in aging models.
What Makes MOTS-c Unique
MOTS-c is the first discovered peptide hormone encoded by mitochondrial DNA, operating as a signaling molecule that communicates mitochondrial status to the rest of the body. TAKR25, the receptor for MOTS-c, is present on cell surfaces throughout the body, allowing systemic metabolic regulation from a mitochondrial signal. When mitochondrial stress occurs, MOTS-c levels increase, triggering compensatory metabolic responses. Researchers investigate how MOTS-c activates cellular stress response pathways, enhances mitochondrial function, improves glucose utilization, and extends metabolic lifespan.
MOTS-c 40mg Research Applications
Preclinical studies document MOTS-c 40mg under investigation for:
- Insulin sensitivity enhancement and glucose homeostasis
- Mitochondrial biogenesis and function improvement
- Metabolic stress resistance and adaptation
- Aging-related metabolic decline reversal
- Autophagy activation and cellular cleanup
- Exercise mimetic effects and physical performance
- NAD+ metabolism and cellular energy regulation
- Anti-inflammatory signaling and metabolic health
MOTS-c Mechanisms: How It Works
MOTS-c binds TAKR25 receptors, activating downstream signaling cascades including AKT and AMPK pathways. These pathways enhance mitochondrial biogenesis, increase insulin sensitivity, activate autophagy, and improve glucose utilization. The net effect is restoration of metabolic homeostasis and cellular stress resistance. MOTS-c 40mg also modulates NAD+ metabolism and sirtuin activation, linking mitochondrial stress signaling to longevity pathways.
Product Specifications
| Compound | MOTS-c (Mitochondrial Open Reading Frame) |
|---|---|
| Quantity | 40mg per vial (lyophilized) |
| Form | Lyophilized powder |
| Purity | ≥99% (HPLC verified) |
| Storage | -20°C (lyophilized); 2-8°C (reconstituted) |
| Appearance | White to off-white lyophilized powder |
| CAS Number | Available on COA |
Quality Verification
- HPLC purity verification (≥99%)
- Mass spectrometry identity confirmation
- Endotoxin and sterility testing
- Certificate of Analysis (COA) included
Frequently Asked Questions
What is MOTS-c?
MOTS-c is a 16-amino-acid mitochondrial-derived peptide that acts as a circulating hormone regulating metabolic homeostasis. Researchers study it for insulin sensitivity, mitochondrial function, and aging-related metabolic health.
How does MOTS-c differ from other peptides?
MOTS-c is unique as a mitochondrial-derived hormone. It signals metabolic status from mitochondria to the body systemically, making it relevant to aging biology and metabolic disease research in ways distinct from tissue-growth peptides.
What is the MOTS-c purity?
≥99% purity verified by HPLC and mass spectrometry. Certificate of Analysis included with every order.
How should MOTS-c be stored?
Store at -20°C lyophilized. After reconstitution with bacteriostatic water, store at 2-8°C and protect from light.
MOTS-c is supplied strictly for laboratory and research use only. Not for human or animal consumption.
Frequently Asked Questions About MOTS-c
Common questions from researchers buying MOTS-c for laboratory studies.
What is MOTS-c used for in research?
MOTS-c is a synthetic peptide extensively studied for its potential applications in tissue regeneration, cellular repair, and molecular biology research. Laboratory studies investigate its mechanisms at the cellular level, including receptor binding, signal transduction, and gene expression pathways. It is widely used in in vitro assays and biochemical profiling.
How do I reconstitute MOTS-c for research?
Reconstitute lyophilized MOTS-c using bacteriostatic water. Slowly inject the diluent along the inner wall of the vial. Do not shake vigorously — gentle swirling is preferred. Allow the peptide to dissolve naturally over 1-2 minutes. Once reconstituted, store the solution at 2-8°C and use within 30 days for optimal stability.
What is the shelf life of lyophilized MOTS-c?
When stored properly at -20°C in a sealed container away from direct light and moisture, lyophilized MOTS-c remains stable for 24-36 months from the date of manufacture. The expiration date is printed on each vial label. Always check the COA for batch-specific stability data.
Is MOTS-c HPLC verified?
Yes. Every batch of CoreVionRX MOTS-c undergoes rigorous High-Performance Liquid Chromatography (HPLC) testing to verify purity of 99% or greater. A Certificate of Analysis (COA) is included with each order, documenting the HPLC chromatogram, mass spectrometry data, and batch-specific test results.
Where can I buy lab grade MOTS-c in the USA?
CoreVionRX supplies high-purity, lab grade MOTS-c directly from our USA-based facility. We offer fast domestic shipping (typically 2-5 business days), discreet packaging, and a 30-day satisfaction guarantee for qualified research applications. All orders ship from within the United States.
What purity level does CoreVionRX MOTS-c guarantee?
CoreVionRX guarantees a minimum purity of 99%+ on all MOTS-c batches. This is verified via HPLC and mass spectrometry, with complete results documented on the included Certificate of Analysis. If a batch does not meet this standard, it is rejected and never shipped to customers.
How should MOTS-c be stored?
Store lyophilized MOTS-c in a freezer at -20°C. Once reconstituted, refrigerate at 2-8°C. Always protect from direct light and moisture. Use within 30 days of reconstitution for optimal stability. Do not freeze reconstituted solution.
What form does MOTS-c come in?
MOTS-c is supplied as a lyophilized (freeze-dried) powder in a sterile glass vial sealed with a rubber stopper. This form maximizes stability during shipping and enables long-term storage. The powder is reconstituted with bacteriostatic water immediately before laboratory use.
Does CoreVionRX ship MOTS-c discreetly?
Yes. All CoreVionRX orders are shipped in plain, unmarked packaging with no indication of contents on the exterior. We prioritize your privacy and the security of your research materials. The return address is generic, and no branding appears on the outside of the package.
Can I return MOTS-c if I am not satisfied?
CoreVionRX offers a 30-day satisfaction guarantee on unopened, properly stored products. Please contact our support team within 30 days of delivery to initiate a return authorization. Items must be in original packaging with the seal intact. Custom or bulk orders may have different return terms.
What is the difference between research grade and lab grade MOTS-c?
CoreVionRX supplies lab grade MOTS-c, which exceeds standard "research grade" definitions. Our peptides undergo more rigorous analytical testing (HPLC + MS), are manufactured under stricter conditions, and come with full documentation. Lab grade is the preferred standard for peer-reviewed research and publication-quality work.
How quickly does CoreVionRX ship MOTS-c orders?
Orders placed before 2:00 PM EST ship the same business day. Standard shipping typically takes 2-5 business days within the continental USA. Express shipping options are available at checkout. You will receive tracking information via email once your MOTS-c order ships.
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Free Shipping Over $250
All orders over $250 ship free within the continental USA. Standard delivery in 2-5 business days.
Discreet Packaging
Plain, unmarked packaging with no indication of contents. Your privacy is our priority.
30-Day Guarantee
Unopened, properly stored products can be returned within 30 days. Contact us for an RA number.
Same-Day Shipping
Orders placed before 2:00 PM EST ship the same business day. Track your package from our facility.
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