AOD9604 10mg (Growth Hormone Fragment) Lab Grade Research Peptide — 99%+ Purity

AOD9604 is a 15-amino-acid fragment peptide derived from the C-terminal region of human growth hormone (hGH) that is studied for its unique metabolic effects. Unlike full-length growth hormone, AOD9604 is investigated specifically for lipid metabolism, fat mobilization, and metabolic regulation without the growth-promoting effects of intact hGH. This AOD9604 10mg lyophilized research peptide is a valuable tool for studying growth hormone signaling, metabolic adaptation, and body composition in preclinical research models.

What Is AOD9604?

AOD9604 (AOD-9604) is a synthetic peptide consisting of 15 amino acids that represents a fragment of the C-terminal region of human growth hormone. Researchers discovered that this specific fragment retains metabolic activities of full-length hGH—particularly lipid mobilization and fat metabolism regulation—while lacking the somatogenic (growth-promoting) effects associated with intact GH. This makes AOD9604 a selective tool for investigating the metabolic compartment of growth hormone signaling, relevant to understanding obesity, metabolic syndrome, and body composition regulation.

AOD9604 Mechanisms of Action

AOD9604 operates through distinct molecular pathways compared to full-length growth hormone. The peptide activates growth hormone receptors (GHR) on adipocytes and other metabolic tissues, triggering intracellular signaling cascades that promote lipolysis (fat breakdown) and inhibit lipogenesis (fat storage). Key mechanisms include activation of hormone-sensitive lipase (HSL), enhanced fatty acid oxidation, and modulation of adipokine secretion. Importantly, AOD9604 does not activate the same receptor conformations or downstream pathways that drive mitogenic (growth) and metabolic effects associated with systemic GH administration, making it a valuable dissociation tool for separating metabolic from growth-regulatory functions.

AOD9604 Research Applications

Preclinical and translational research documents AOD9604 investigation for:

• Lipid mobilization and fat oxidation pathways
• Metabolic syndrome and obesity models
• Insulin sensitivity and glucose homeostasis
• Body composition and lean mass preservation
• Adipocyte function and lipolysis regulation
• GH receptor signaling dissociation (metabolic vs. growth)
• Energy expenditure and resting metabolic rate
• Cardiovascular metabolic markers
• Weight management and fat loss research

AOD9604 vs. Full-Length Growth Hormone

Full-length human growth hormone (hGH, 191 amino acids) exerts both anabolic (muscle/bone growth) and metabolic (fat loss, glucose regulation) effects. AOD9604, derived from the hGH C-terminus, selectively preserves metabolic activities while eliminating mitogenic signaling. This dissociation is scientifically valuable: researchers can study fat metabolism independently of growth effects, and AOD9604 avoids the somatogenic side effects that complicate interpretation of full hGH studies. For research focused purely on lipid metabolism and metabolic adaptation, AOD9604 offers a more targeted tool.

AOD9604 History & Research Context

AOD9604 was developed and investigated by Australian Biotechnology Company (ABC) in the late 1990s and early 2000s as a potential therapeutic for weight management and metabolic disorders. It progressed through preclinical and human clinical studies examining effects on body composition, lipid profiles, and metabolic markers. While clinical development has varied, AOD9604 remains an active research compound in both preclinical models and investigator-initiated studies examining GH receptor biology and metabolic regulation.

AOD9604 Specifications

Compound	AOD9604 (Growth Hormone Fragment, 15-amino-acid peptide)
Quantity	10mg per vial (lyophilized)
Form	Lyophilized powder
Purity	≥99% (HPLC verified)
Sequence	C-terminal fragment of human growth hormone (hGH residues 177-191)
Molecular Weight	Available on COA
Storage	-20°C (lyophilized); 2-8°C (reconstituted)
CAS Number	Available on COA
Appearance	White to off-white lyophilized powder
Packaging	Sealed sterile glass vial

Quality Verification

• HPLC purity verification (≥99%)
• Mass spectrometry sequence and identity confirmation
• Amino acid composition analysis
• Endotoxin and microbial contamination testing
• Certificate of Analysis (COA) included with every order

Reconstitution & Handling

AOD9604 10mg is reconstituted with bacteriostatic water for laboratory research. Add the diluent slowly down the inside wall of the vial to ensure complete dissolution without foaming. Once reconstituted, store the solution at 2-8°C and protect from light. Prepare aliquots to avoid repeated freeze-thaw cycles. Always follow institutional protocols for peptide handling, storage, and documentation in compliance with research regulations.

Frequently Asked Questions

What is AOD9604 and how does it differ from growth hormone?

AOD9604 is a 15-amino-acid fragment of the C-terminal region of human growth hormone. It retains metabolic activities (fat mobilization, lipid oxidation) but lacks the growth-promoting effects of intact hGH, making it a selective tool for studying metabolism independent of growth signaling.

How does AOD9604 affect fat metabolism?

AOD9604 activates GH receptors on adipocytes and metabolic tissues, promoting lipolysis (fat breakdown) through activation of hormone-sensitive lipase and enhanced fatty acid oxidation while inhibiting lipogenesis (fat storage).

What is the purity of CoreVionRX AOD9604?

CoreVionRX AOD9604 10mg is ≥99% purity, verified by HPLC and confirmed by mass spectrometry. Sequence identity and amino acid composition are verified. Each batch includes a Certificate of Analysis documenting purity, molecular weight, and sterility testing.

How should AOD9604 be stored and reconstituted?

Store the lyophilized vial at -20°C for maximum stability. Reconstitute with bacteriostatic water by adding slowly down the vial wall. After reconstitution, store at 2-8°C, protect from light, and prepare small aliquots to avoid freeze-thaw cycles.AOD9604 is supplied strictly for laboratory and research use only. Not for human or animal consumption.