COA included with every order For laboratory research use only
HPLC Verified≥98% purity confirmed per lot
COA IncludedLot-specific certificate ships with order
Mass Spec IDMolecular identity confirmed per batch
USA OperationsVerified sourcing. Documented chain.
About This Compound
What Is Ipamorelin?
Ipamorelin is a synthetic pentapeptide growth hormone secretagogue (GHS) and selective agonist of the ghrelin receptor (GHS-R1a). Its sequence — Aib-His-D-2-Nal-D-Phe-Lys-NH2 — includes non-natural amino acids that confer receptor selectivity and metabolic stability. It was identified in 1998 as one of the cleanest GHSPs due to its highly selective receptor profile.
In preclinical research, Ipamorelin is studied for its selective GH release without concurrent elevation of cortisol, prolactin, or ACTH — a significant distinction from earlier GHRPs. Researchers use it to investigate GHS-R1a pharmacology, pulsatile GH release kinetics, and metabolic effects of GH axis stimulation.
CoreVionRX doesn’t manufacture peptides. What we do — rigorously — is verify every batch before it reaches our catalog.
≥98%
Purity by Reversed-Phase HPLC
HPLC separates the compound from any impurities and measures the exact purity percentage. The chromatogram is documented on your COA.
MS/MS
Mass Spectrometry Identity Check
Electrospray ionization mass spectrometry verifies the molecular weight matches the compound specification. Confirms you’re getting the actual compound.
Lot #
Lot-Specific Certificate of Analysis
Your COA is tied to your specific production lot — not a generic document. This is not standard practice in this market. We made it one anyway.
100%
Documented Before Listing
No compound reaches our catalog without clearing our verification process first. If documentation isn’t available for a batch, that batch doesn’t ship.
Technical Specifications
Full Product Data
Everything you need to evaluate this compound for your research protocol.
Specification
Value
Compound
Ipamorelin
Sequence
Aib-His-D-2-Nal-D-Phe-Lys-NH₂
Amino Acids
5 (pentapeptide, includes non-natural residues)
Receptor Target
GHS-R1a (ghrelin receptor) — selective
Form
Lyophilized powder
Vial Size
5mg per vial
Purity
≥98% by reversed-phase HPLC
Identity
Confirmed by electrospray ionization mass spectrometry
Storage (lyophilized)
−20°C, protected from light and moisture. Stable 24+ months.
Reconstitution
Bacteriostatic water — typical 1–2mg/mL
Documentation
Lot-specific COA with HPLC chromatogram — included with every order
Preclinical Research
What Researchers Study Ipamorelin For
All published research is preclinical — cell cultures and animal models. No human clinical trial data exists for Ipamorelin. Here’s where the science currently stands.
GHS-R1a Receptor Research
Ipamorelin is studied as a highly selective GHS-R1a agonist. Research examines receptor binding kinetics, downstream signal transduction via cAMP and intracellular calcium pathways, and the selectivity profile compared to non-selective GHRPs.
Raun K. et al. (1998) Eur J Endocrinol 139(5):552-61
Selective GH Release Studies
A key research focus is Ipamorelin’s ability to stimulate GH release without elevating cortisol, prolactin, or ACTH — unlike first-generation GHRPs. This selectivity makes it a useful pharmacological tool for isolating GH-specific effects.
Johansen PB. et al. (1999) Growth Horm IGF Res 9(3):175-82
Metabolic & Body Composition Research
In rodent models, Ipamorelin-induced GH elevation is studied for downstream effects on IGF-1 production, lean mass, adipose tissue metabolism, and bone density — representing the downstream consequences of selective GHS-R1a activation.
Svensson J. et al. (2000) J Endocrinol 166(2):269-77
Why CoreVionRX
Documentation Is the Product.
Most peptide vendors claim purity. We document it. Every compound ships with independent lab verification — not because regulations require it, but because you deserve to know exactly what you’re working with.
Independent HPLC Testing
Every batch runs through reversed-phase HPLC before we list it. The chromatogram appears on your COA. Verify the peak profile yourself.
Lot-Specific Documentation
Your COA is tied to your production lot — not a template document. “COA available upon request” is not how we operate.
Transparent About What We Are
We source and verify. We are not a synthesis lab. That honesty is deliberate — it’s the only way to build a brand worth buying from twice.
Lyophilized for Stability
Ships as lyophilized powder — stable at −20°C for 24+ months. Full integrity maintained until you’re ready to reconstitute.
Common Questions
Straight Answers.
What is Ipamorelin and how does it work?
Ipamorelin is a synthetic pentapeptide that selectively activates the ghrelin receptor (GHS-R1a) — the primary receptor mediating growth hormone secretagogue effects. Unlike ghrelin itself, Ipamorelin does not activate receptors for cortisol, prolactin, or ACTH, making it a highly selective research tool for studying GH axis pharmacology.
What makes Ipamorelin different from other GHRPs?
Ipamorelin’s selectivity distinguishes it. First-generation GHRPs (GHRP-2, GHRP-6) elevate cortisol, prolactin, and ACTH alongside GH. Ipamorelin was specifically designed to eliminate these off-target effects, enabling researchers to study GHS-R1a-mediated GH release in isolation.
Is Ipamorelin often studied with CJC-1295?
Yes. Ipamorelin (GHS-R1a agonist) and CJC-1295 with DAC (GHRH receptor agonist) are frequently combined in research protocols because they act on complementary GH-stimulating pathways. We also carry the pre-combined blend.
How do I reconstitute Ipamorelin?
Reconstitute with bacteriostatic water. Typical research concentrations: 1–2mg/mL. Gently swirl — do not shake. Use our reconstitution calculator for exact volumes. Store reconstituted solution at 2–8°C.
How should Ipamorelin be stored?
Store lyophilized at −20°C, protected from light and moisture. Stable for 24+ months. After reconstitution, store at 2–8°C. Aliquot before reconstituting to minimize freeze-thaw cycles.
For laboratory research use only. Not for human or animal consumption. CoreVionRX supplies research compounds to qualified laboratories and research institutions.
Ipamorelin Research Peptide: What to Know Before You Buy
ipamorelin research peptide from CoreVionRX is verified at ≥99%% HPLC purity with mass spectrometry confirming the exact peptide sequence.
Every ipamorelin research peptide vial ships with HPLC verification and a lot-specific COA.
Every vial of ipamorelin research peptide ships with a lot-specific certificate of analysis so you can verify exactly what is in the vial you received.
CoreVionRX ipamorelin research peptide is verified by independent third-party testing — mass spectrometry confirms sequence identity and HPLC confirms purity.
Store ipamorelin research peptide as a lyophilized powder in cool, dark conditions; once reconstituted, keep refrigerated and use within your protocol window.
For accurate reconstitution of ipamorelin research peptide, use the peptide calculator to calculate the exact water volume needed.
Researchers working with ipamorelin research peptide should confirm ≥99%% HPLC purity and a lot-specific COA with every order.
For reconstitution, add bacteriostatic water slowly and store ipamorelin research peptide refrigerated after mixing. Use the peptide calculator to get concentration right.
When sourcing ipamorelin research peptide, the most important check is purity: every CoreVionRX vial is verified at ≥99% HPLC with a lot-specific COA.
Peer-reviewed research on ipamorelin research peptide is indexed at PubMed. For research use only.
All CoreVionRX research peptides ship with a lot-specific COA, ≥99%% HPLC purity, and mass-spec identity confirmation. Use our reconstitution calculator for prep. For research use only.
Sourcing verified ipamorelin research peptide is the first step in any reliable research protocol.
