Ipamorelin — 5-residue GHRP mimetic (Aib-His-D-2-Nal-D-Phe-Lys-NH2) and selective GHS-R1a agonist. Studied for clean growth hormone release without cortisol or prolactin elevation. 5mg lyophilized, HPLC + mass spec verified.
Ipamorelin is a synthetic pentapeptide growth hormone secretagogue (GHS) and selective agonist of the ghrelin receptor (GHS-R1a). Its sequence — Aib-His-D-2-Nal-D-Phe-Lys-NH2 — includes non-natural amino acids that confer receptor selectivity and metabolic stability. It was identified in 1998 as one of the cleanest GHSPs due to its highly selective receptor profile.
In preclinical research, Ipamorelin is studied for its selective GH release without concurrent elevation of cortisol, prolactin, or ACTH — a significant distinction from earlier GHRPs. Researchers use it to investigate GHS-R1a pharmacology, pulsatile GH release kinetics, and metabolic effects of GH axis stimulation.
For a full breakdown of the research literature, read our Ipamorelin research guide →
CoreVionRX doesn’t manufacture peptides. What we do — rigorously — is verify every batch before it reaches our catalog.
Everything you need to evaluate this compound for your research protocol.
| Specification | Value |
|---|---|
| Compound | Ipamorelin |
| Sequence | Aib-His-D-2-Nal-D-Phe-Lys-NH₂ |
| Amino Acids | 5 (pentapeptide, includes non-natural residues) |
| Receptor Target | GHS-R1a (ghrelin receptor) — selective |
| Form | Lyophilized powder |
| Vial Size | 5mg per vial |
| Purity | ≥98% by reversed-phase HPLC |
| Identity | Confirmed by electrospray ionization mass spectrometry |
| Storage (lyophilized) | −20°C, protected from light and moisture. Stable 24+ months. |
| Reconstitution | Bacteriostatic water — typical 1–2mg/mL |
| Documentation | Lot-specific COA with HPLC chromatogram — included with every order |
All published research is preclinical — cell cultures and animal models. No human clinical trial data exists for Ipamorelin. Here’s where the science currently stands.
Raun K. et al. (1998) Eur J Endocrinol 139(5):552-61
Johansen PB. et al. (1999) Growth Horm IGF Res 9(3):175-82
Svensson J. et al. (2000) J Endocrinol 166(2):269-77
Most peptide vendors claim purity. We document it. Every compound ships with independent lab verification — not because regulations require it, but because you deserve to know exactly what you’re working with.
In stock. COA included. HPLC + mass spec verified. Ships with full documentation.
For laboratory research use only. Not for human or animal consumption.
CoreVionRX supplies research compounds to qualified laboratories and research institutions.
Documentation & Testing Standards
Every batch is independently tested before release. Research peptide FAQs · CoreVionRX testing standards
Related Research Compounds