Research Compound · Thymosin Alpha-1

Thymosin Alpha-1 Research Peptide —
Independently Verified.

Thymosin Alpha-1 (TA-1) — 28-amino-acid thymic peptide studied for T-cell maturation, dendritic cell activation, and immune signaling pathways in preclinical models. 10mg lyophilized, HPLC + mass spec verified.

≥98% HPLC PurityMass Spec VerifiedLyophilized · 10mgCOA IncludedUSA Operations

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$75.00

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Mass Spec IDIdentity confirmed per batch

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About This Compound

What Is Thymosin Alpha-1?

Thymosin Alpha-1 (TA-1) is a 28-amino-acid peptide naturally secreted by the thymus gland. It was first isolated by Allan Goldstein in 1977 as the active component of Thymosin Fraction 5 — a thymic extract studied for immune modulation. A synthetic version (Thymalfasin) has received pharmaceutical approval in some countries for hepatitis B and C treatment.

In preclinical research, Thymosin Alpha-1 is studied for its effects on T-lymphocyte maturation, dendritic cell activation, NK cell function, and regulatory T-cell modulation. It is one of the most extensively studied thymic peptides in immune system research.

Read our Thymosin Alpha-1 research guide →

// compound profile

CompoundThymosin Alpha-1 (TA-1)

Amino Acids28

OriginSynthetic thymic peptide

FormLyophilized powder

Size10mg per vial

Purity≥98% HPLC

Storage−20°C / 24+ months

Quality Standard

We Verify Before We Ship.

CoreVionRX doesn’t manufacture compounds. We verify every batch rigorously before it reaches our catalog.

≥98%

Purity by HPLC

Reversed-phase HPLC separates and measures compound purity. Documented on your lot-specific COA.

MS/MS

Mass Spec Identity

Molecular weight verified by ESI mass spectrometry — confirms you’re getting exactly what you ordered.

Lot #

Lot-Specific COA

Your COA tied to your production lot. Not standard in this market. We made it standard anyway.

100%

Pre-Listing Verification

No compound ships without full documentation cleared. Non-negotiable policy.

Technical Specifications

Full Product Data

Specification	Value
Compound	Thymosin Alpha-1 (Thymalfasin, TA-1)
Amino Acids	28
Origin	Synthetic analog of thymus-secreted peptide
Form	Lyophilized powder
Vial Size	10mg per vial
Purity	≥98% by reversed-phase HPLC
Identity	Confirmed by electrospray ionization mass spectrometry
Storage (lyophilized)	−20°C, protected from light and moisture. Stable 24+ months.
Reconstitution	Bacteriostatic water or sterile water
Documentation	Lot-specific COA with HPLC chromatogram — included with every order

Preclinical Research

What Researchers Study Thymosin Alpha-1 For

All published research is preclinical — cell cultures and animal models.

T-Cell Modulation Research

Thymosin Alpha-1 is studied for its role in T-lymphocyte maturation and subset differentiation — particularly Th1/Th2 balance and regulatory T-cell (Treg) activity. Research examines how TA-1 modulates T-cell responses in vitro and in immunocompromised animal models.

Goldstein AL. & Garaci E. (2007) Ann N Y Acad Sci 1112:1-7

Dendritic Cell Activation

Preclinical research investigates Thymosin Alpha-1’s effects on dendritic cell maturation and antigen presentation — key to adaptive immune system priming. Studies examine TLR signaling pathway modulation and cytokine production in DC cultures.

Romani L. et al. (2007) Blood 109(2):543-52

NK Cell & Antiviral Research

Research examines Thymosin Alpha-1’s effects on natural killer (NK) cell activity and antiviral immune responses in preclinical models — exploring its potential as an immune adjuvant in combination research protocols.

Tuthill CW. & Rios A. (1994) Int J Immunopharmacol 16(3):181-9

Why CoreVionRX

Documentation Is the Product.

Most vendors claim purity. We document it. Every compound ships with independent lab verification.

Independent HPLC Testing

Every batch through reversed-phase HPLC before listing. Chromatogram on your COA.

Lot-Specific COA

Your COA tied to your production lot — not a generic template.

Transparent Sourcing

We source and verify. Not a synthesis lab. That honesty builds the brand.

Stability Guaranteed

Lyophilized powder — stable at −20°C for 24+ months.

Common Questions

Straight Answers.

What is Thymosin Alpha-1 and where does it come from?

Thymosin Alpha-1 is a 28-amino-acid peptide naturally secreted by the thymus gland. First isolated in 1977 by Allan Goldstein, it was identified as the active component of Thymosin Fraction 5. The research compound is a synthetic version. A pharmaceutical form (Thymalfasin) exists for clinical use in some countries — the research compound is sold separately for preclinical research.

What research areas use Thymosin Alpha-1?

Research focuses on T-lymphocyte maturation, Th1/Th2 balance, regulatory T-cell modulation, dendritic cell activation, NK cell function, and antiviral immune response research. All CoreVionRX compound sales are for preclinical research use only.

How does Thymosin Alpha-1 differ from Thymosin Beta-4 (TB-500)?

Despite similar names, these are completely different peptides with different structures and mechanisms. Thymosin Alpha-1 is a 28-aa thymic peptide studied for immune modulation. Thymosin Beta-4 (TB-500) is a 43-aa actin-binding peptide studied for tissue repair. They belong to different protein families.

How do I reconstitute Thymosin Alpha-1?

Reconstitute with bacteriostatic water or sterile water. Typical research concentrations: 1–5mg/mL. Inject water slowly down the vial wall, swirl gently. Store reconstituted solution at 2–8°C.

How should Thymosin Alpha-1 be stored?

Store lyophilized at −20°C, protected from light and moisture. Stable for 24+ months. After reconstitution, store at 2–8°C. Aliquot before reconstituting to minimize freeze-thaw cycles.

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≥98% HPLCLot-Specific COAMass Spec VerifiedUSA Operations

For laboratory research use only. Not for human or animal consumption.

Thymosin Alpha-1 Research Peptide —Independently Verified.