Semax — synthetic heptapeptide analog of ACTH(4-10). Studied for neuroprotective effects, BDNF modulation, and cognitive pathway research in preclinical models. 10mg lyophilized, HPLC + mass spec verified.
Semax is a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) derived from the ACTH(4-10) sequence — a fragment of adrenocorticotropic hormone. It was originally developed in Russia in the 1980s and has been extensively studied in preclinical models for its effects on brain-derived neurotrophic factor (BDNF) expression and neuroprotection.
In preclinical research, Semax is investigated for its role in BDNF upregulation, neuroprotective pathways, HPA axis modulation, and cognitive function studies. It is one of the more extensively studied nootropic peptides in Russian academic literature.
For a full breakdown of the research literature, read our Semax research guide →
CoreVionRX doesn’t manufacture peptides. What we do — rigorously — is verify every batch before it reaches our catalog.
Everything you need to evaluate this compound for your research protocol.
| Specification | Value |
|---|---|
| Compound | Semax (ACTH 4-10 Heptapeptide) |
| Sequence | Met-Glu-His-Phe-Pro-Gly-Pro |
| Amino Acids | 7 (heptapeptide) |
| Origin | Synthetic analog of ACTH(4-10) fragment |
| Form | Lyophilized powder |
| Vial Size | 10mg per vial |
| Purity | ≥98% by reversed-phase HPLC |
| Identity | Confirmed by electrospray ionization mass spectrometry |
| Storage (lyophilized) | −20°C, protected from light and moisture. Stable 24+ months. |
| Reconstitution | Bacteriostatic water |
| Documentation | Lot-specific COA with HPLC chromatogram — included with every order |
All published research is preclinical — cell cultures and animal models. No human clinical trial data exists for Semax. Here’s where the science currently stands.
Dolotov OV. et al. (2006) J Mol Neurosci 28(3):281-91
Manchenko DM. et al. (2012) Bull Exp Biol Med 153(4):544-7
Miasoedov NF. et al. (1999) Neurosci Behav Physiol 29(4):369-75
Most peptide vendors claim purity. We document it. Every compound ships with independent lab verification — not because regulations require it, but because you deserve to know exactly what you’re working with.
In stock. COA included. HPLC + mass spec verified. Ships with full documentation.
For laboratory research use only. Not for human or animal consumption.
CoreVionRX supplies research compounds to qualified laboratories and research institutions.
Documentation & Testing Standards
Every batch is independently tested before release. Research peptide FAQs · CoreVionRX testing standards
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