Research Compound · Melanotan II

Melanotan II Research Peptide —
Independently Verified.

Melanotan II — cyclic heptapeptide melanocortin agonist. Studied for MC1R pigmentation pathways, melanogenesis, and melanocortin receptor research in preclinical models. 10mg lyophilized, HPLC + mass spec verified.

≥98% HPLC PurityMass Spec VerifiedLyophilized · 10mgCOA IncludedUSA Operations

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For laboratory research use only

HPLC Verified≥98% purity confirmed per lot

COA IncludedLot-specific certificate

Mass Spec IDIdentity confirmed per batch

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About This Compound

What Is Melanotan II?

Melanotan II (MT-II) is a synthetic cyclic analog of alpha-melanocyte-stimulating hormone (α-MSH) — a non-selective melanocortin receptor agonist that binds MC1R, MC3R, MC4R, and MC5R. It was originally developed at the University of Arizona in the 1980s as a research compound to investigate melanogenesis and photoprotection mechanisms.

In preclinical research, Melanotan II is primarily studied for its MC1R-mediated effects on melanogenesis and skin pigmentation in cell culture and animal models. It is also studied as a pharmacological tool for investigating MC3R/MC4R receptor pathways related to energy balance — though with less selectivity than its derivative PT-141.

Read our Melanotan II research guide →

// compound profile

CompoundMelanotan II (MT-II)

StructureCyclic heptapeptide

Receptor TargetsMC1R, MC3R, MC4R, MC5R

FormLyophilized powder

Size10mg per vial

Purity≥98% HPLC

Storage−20°C / protected from light

Quality Standard

We Verify Before We Ship.

CoreVionRX doesn’t manufacture compounds. We verify every batch rigorously before it reaches our catalog.

≥98%

Purity by HPLC

Reversed-phase HPLC separates and measures compound purity. Documented on your lot-specific COA.

MS/MS

Mass Spec Identity

Molecular weight verified by ESI mass spectrometry — confirms you’re getting exactly what you ordered.

Lot #

Lot-Specific COA

Your COA tied to your production lot. Not standard in this market. We made it standard anyway.

100%

Pre-Listing Verification

No compound ships without full documentation cleared. Non-negotiable policy.

Technical Specifications

Full Product Data

Specification	Value
Compound	Melanotan II (MT-II)
Structure	Cyclic heptapeptide — α-MSH analog
Receptor Targets	MC1R, MC3R, MC4R, MC5R (non-selective)
Form	Lyophilized powder
Vial Size	10mg per vial
Purity	≥98% by reversed-phase HPLC
Identity	Confirmed by electrospray ionization mass spectrometry
Storage (lyophilized)	−20°C, protected from light and moisture. Stable 24+ months.
Storage (reconstituted)	2–8°C, away from light
Reconstitution	Bacteriostatic water
Documentation	Lot-specific COA with HPLC chromatogram — included with every order

Preclinical Research

What Researchers Study Melanotan II For

All published research is preclinical — cell cultures and animal models.

MC1R Pigmentation Research

Melanotan II’s agonism at MC1R — the primary melanocyte receptor — makes it a key research tool for studying melanogenesis, melanin synthesis pathways, and UV-independent tanning mechanisms in melanocyte cultures and animal models.

Hadley ME. et al. (1998) Ann N Y Acad Sci 885:1-18

Melanocortin Receptor Pharmacology

As a non-selective agonist across MC1R-MC5R, MT-II is used in receptor pharmacology research to characterize downstream signaling pathways, compare receptor selectivity profiles, and develop the science that led to more selective analogs like PT-141.

Cone RD. (2006) Nat Neurosci 9(8):1019-23

Melanogenesis Studies

Preclinical research examines the molecular mechanisms of Melanotan II-induced melanogenesis — cAMP elevation, MITF transcription factor activation, tyrosinase upregulation — providing insights into pigmentation biology and melanoma research.

Rouzaud F. et al. (2003) Cell Mol Life Sci 60(9):1912-20

Why CoreVionRX

Documentation Is the Product.

Most vendors claim purity. We document it. Every compound ships with independent lab verification.

Independent HPLC Testing

Every batch through reversed-phase HPLC before listing. Chromatogram on your COA.

Lot-Specific COA

Your COA tied to your production lot — not a generic template.

Transparent Sourcing

We source and verify. Not a synthesis lab. That honesty builds the brand.

Stability Guaranteed

Lyophilized powder — stable at −20°C for 24+ months.

Common Questions

Straight Answers.

What is Melanotan II and how does it relate to PT-141?

Melanotan II is a non-selective melanocortin agonist acting on MC1R, MC3R, MC4R, and MC5R. PT-141 (Bremelanotide) is a cyclic derivative of Melanotan II engineered to selectively target MC3R/MC4R — the CNS receptors — while minimizing MC1R pigmentation effects. MT-II is used when broad-spectrum melanocortin receptor research is required.

What research areas use Melanotan II?

Research focuses on melanogenesis and MC1R-mediated pigmentation, melanocortin receptor pharmacology (comparing MC1R-5R activity profiles), MITF transcription factor research, and UV-independent melanin synthesis in cell culture models.

How do I reconstitute Melanotan II?

Reconstitute with bacteriostatic water. Typical research concentrations: 1–2mg/mL. Inject water slowly down the vial wall, swirl gently. Protect from light during preparation and storage. Use our reconstitution calculator for exact volumes.

How should Melanotan II be stored?

Store lyophilized at −20°C, protected from light and moisture. Stable for 24+ months. After reconstitution, store at 2–8°C away from light. Light protection is particularly important for melanocortin compounds.

Is Melanotan II a research-only compound?

Yes. Melanotan II is sold by CoreVionRX strictly as a research compound for laboratory use. It is not approved for human use by any regulatory body and is not for human or animal consumption. For laboratory research purposes only.

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≥98% HPLCLot-Specific COAMass Spec VerifiedUSA Operations

For laboratory research use only. Not for human or animal consumption.

Melanotan II Research Peptide —Independently Verified.