This PT-141 research peptide guide covers purity verification, quality standards, and handling for melanocortin research.
Research Compound · PT-141
PT-141 Research Peptide — Independently Verified.
PT-141 (Bremelanotide) — cyclic heptapeptide melanocortin receptor agonist. Studied for MC3R and MC4R signaling pathways and CNS receptor research in preclinical models. 10mg lyophilized, HPLC + mass spec verified.
COA included with every order For laboratory research use only
HPLC Verified≥98% purity confirmed per lot
COA IncludedLot-specific certificate ships with order
Mass Spec IDMolecular identity confirmed per batch
USA OperationsVerified sourcing. Documented chain.
About This Compound
What Is PT-141?
PT-141 (Bremelanotide) is a synthetic cyclic heptapeptide and melanocortin receptor agonist derived from Melanotan II. Unlike Melanotan II, PT-141 is a cyclic structure that acts specifically on melanocortin receptor subtypes MC3R and MC4R — receptors expressed in the central nervous system — rather than the peripheral MC1R melanocyte receptor.
In preclinical research, PT-141 is investigated for its melanocortin receptor signaling properties, CNS pathway activation, and the downstream effects of MC3R/MC4R agonism on energy balance and neural signaling. It has also undergone clinical investigation — making it one of the few research peptides with FDA-approved drug status (Vyleesi).
CoreVionRX doesn’t manufacture peptides. What we do — rigorously — is verify every batch before it reaches our catalog.
≥98%
Purity by Reversed-Phase HPLC
HPLC separates the compound from any impurities and measures the exact purity percentage. The chromatogram is documented on your COA — not a number we made up.
MS/MS
Mass Spectrometry Identity Check
Electrospray ionization mass spectrometry verifies the molecular weight matches the compound specification. This confirms you’re getting the actual compound — not a substitute or mis-labeled batch.
Lot #
Lot-Specific Certificate of Analysis
Your COA is tied to your specific production lot — not a generic document. This is not standard practice in this market. We made it one anyway.
100%
Documented Before Listing
No compound reaches our catalog without clearing our verification process first. If documentation isn’t available for a batch, that batch doesn’t ship.
Technical Specifications
Full Product Data
Everything you need to evaluate this compound for your research protocol.
Specification
Value
Compound
PT-141 (Bremelanotide)
Structure
Cyclic heptapeptide melanocortin agonist
Receptor Targets
MC3R, MC4R (central melanocortin receptors)
Origin
Derivative of Melanotan II — cyclic analog
Form
Lyophilized powder
Vial Size
10mg per vial
Purity
≥98% by reversed-phase HPLC
Identity
Confirmed by electrospray ionization mass spectrometry
Storage (lyophilized)
−20°C, protected from light and moisture. Stable 24+ months.
Storage (reconstituted)
2–8°C, away from light
Reconstitution
Bacteriostatic water
Documentation
Lot-specific COA with HPLC chromatogram — included with every order
Preclinical Research
What Researchers Study PT-141 For
All published research is preclinical — cell cultures and animal models. No human clinical trial data exists for PT-141. Here’s where the science currently stands.
Melanocortin Receptor Research
PT-141 is studied as a selective agonist for MC3R and MC4R — melanocortin receptor subtypes expressed in the central nervous system. Research investigates receptor binding kinetics, downstream signaling cascades, and selectivity profiles.
Wessells H. et al. (2003) J Urol 170(1):116-9
CNS Signaling Studies
Unlike peripherally-acting melanocortin agonists, PT-141 crosses the blood-brain barrier to act on central MC3R/MC4R. Research examines CNS pathway modulation including hypothalamic signaling relevant to energy regulation.
Diamond LE. et al. (2004) J Urol 172(5 Pt 1):1999-2004
Energy Balance Research
MC4R agonism has established roles in energy homeostasis. PT-141 is used as a pharmacological tool to investigate MC4R-mediated pathways related to appetite regulation and energy expenditure in rodent models.
Cone RD. (2006) Nat Neurosci 9(8):1019-23
Why CoreVionRX
Documentation Is the Product.
Most peptide vendors claim purity. We document it. Every compound ships with independent lab verification — not because regulations require it, but because you deserve to know exactly what you’re working with.
Independent HPLC Testing
Every batch runs through reversed-phase HPLC before we list it. The chromatogram appears on your COA. Verify the peak profile yourself.
Lot-Specific Documentation
Your COA is tied to your production lot — not a template document used across all orders. “COA available upon request” is not how we operate.
Transparent About What We Are
We source and verify. We are not a synthesis lab. That honesty is deliberate — it’s the only way to build a brand worth buying from twice.
Lyophilized for Stability
Ships as lyophilized powder — stable at −20°C for 24+ months. Full integrity maintained until you’re ready to reconstitute.
Common Questions
Straight Answers.
What is PT-141 (Bremelanotide) and how does it differ from Melanotan II?
PT-141 is a cyclic heptapeptide derived from Melanotan II, engineered to selectively target MC3R and MC4R — central nervous system melanocortin receptors — rather than the peripheral MC1R responsible for skin pigmentation. This makes it a CNS-focused research tool. Bremelanotide is the INN for the compound (FDA-approved as Vyleesi for one clinical indication — the research compound is sold separately for preclinical use).
What research areas use PT-141?
PT-141 is studied for MC3R/MC4R receptor pharmacology, CNS melanocortin signaling, energy balance regulation, and hypothalamic pathway research. Research is conducted in cell culture and rodent models.
How do I reconstitute PT-141?
Reconstitute with bacteriostatic water. Typical research concentrations: 1–2mg/mL. PT-141 is a cyclic peptide and dissolves readily. Inject water slowly down the vial wall, swirl gently. Use our reconstitution calculator for exact volumes.
How should PT-141 be stored?
Store lyophilized at −20°C, protected from light and moisture. Stable for 24+ months. After reconstitution, store at 2–8°C away from light. Aliquot before reconstituting to minimize freeze-thaw exposure.
Is PT-141 a research-only compound?
In the United States, PT-141 (Bremelanotide) is sold by CoreVionRX strictly as a research compound for laboratory use. It is not for human or animal consumption outside of authorized clinical settings. The FDA-approved drug form (Vyleesi) is a separate pharmaceutical product. Research compounds are used for in vitro and preclinical research purposes only.
For laboratory research use only. Not for human or animal consumption. CoreVionRX supplies research compounds to qualified laboratories and research institutions.
PT-141 Research Peptide: What to Know Before You Buy
pt-141 research peptide from CoreVionRX is verified at ≥99%% HPLC purity with mass spectrometry confirming the exact peptide sequence.
Every pt-141 research peptide vial ships with HPLC verification and a lot-specific COA.
Every vial of pt-141 research peptide ships with a lot-specific certificate of analysis so you can verify exactly what is in the vial you received.
CoreVionRX pt-141 research peptide is verified by independent third-party testing — mass spectrometry confirms sequence identity and HPLC confirms purity.
Store pt-141 research peptide as a lyophilized powder in cool, dark conditions; once reconstituted, keep refrigerated and use within your protocol window.
For accurate reconstitution of pt-141 research peptide, use the peptide calculator to calculate the exact water volume needed.
Researchers working with pt-141 research peptide should confirm ≥99%% HPLC purity and a lot-specific COA with every order.
For reconstitution, add bacteriostatic water slowly and store pt-141 research peptide refrigerated after mixing. Use the peptide calculator to get concentration right.
When sourcing pt-141 research peptide, the most important check is purity: every CoreVionRX vial is verified at ≥99% HPLC with a lot-specific COA.
Peer-reviewed research on pt-141 research peptide is indexed at PubMed. For research use only.
All CoreVionRX research peptides ship with a lot-specific COA, ≥99%% HPLC purity, and mass-spec identity confirmation. Use our reconstitution calculator for prep. For research use only.
Sourcing verified pt-141 research peptide is the first step in any reliable research protocol.
